Finding the optimum activation energy in DNA breathing dynamics: A Simulated Annealing approach

We demonstrate how the stochastic global optimization scheme of Simulated Annealing can be used to evaluate optimum parameters in the problem of DNA breathing dynamics. The breathing dynamics is followed in accordance with the stochastic Gillespie scheme with the denaturation zones in double stranded DNA studied as a single molecule time series. Simulated Annealing is used to find the optimum value of the activation energy for which the equilibrium bubble size distribution matches with a given value. It is demonstrated that the method overcomes even large noise in the input surrogate data.Comment: 9 pages, 4 figures, iop article package include

Self Running Droplet: Emergence of Regular Motion from Nonequilibrium Noise

Spontaneous motion of an oil droplet driven by chemical nonequilibricity is reported. It is shown that the droplet undergoes regular rhythmic motion under appropriately designed boundary conditions, whereas it exhibits random motion in an isotropic environment. This study is a novel manifestation on the direct energy transformation of chemical energy into regular spatial-motion under isothermal conditions. A simple mathematical equation including noise reproduces the essential feature of the transition from irregularity into periodic regular motion. Our results will inspire the theoretical study on the mechanism of molecular motors in living matter, working under significant influence of thermal fluctuation.Comment: 4 pages, 4 figure

Spontaneous heavy cluster emission rates using microscopic potentials

The nuclear cluster radioactivities have been studied theoretically in the framework of a microscopic superasymmetric fission model (MSAFM). The nuclear interaction potentials required for binary cold fission processes are calculated by folding in the density distribution functions of the two fragments with a realistic effective interaction. The microscopic nuclear potential thus obtained has been used to calculate the action integral within the WKB approximation. The calculated half lives of the present MSAFM calculations are found to be in good agreement over a wide range of observed experimental data.Comment: 4 pages, 4 figure

Optical Flow Estimation in the Deep Learning Age

Akin to many subareas of computer vision, the recent advances in deep learning have also significantly influenced the literature on optical flow. Previously, the literature had been dominated by classical energy-based models, which formulate optical flow estimation as an energy minimization problem. However, as the practical benefits of Convolutional Neural Networks (CNNs) over conventional methods have become apparent in numerous areas of computer vision and beyond, they have also seen increased adoption in the context of motion estimation to the point where the current state of the art in terms of accuracy is set by CNN approaches. We first review this transition as well as the developments from early work to the current state of CNNs for optical flow estimation. Alongside, we discuss some of their technical details and compare them to recapitulate which technical contribution led to the most significant accuracy improvements. Then we provide an overview of the various optical flow approaches introduced in the deep learning age, including those based on alternative learning paradigms (e.g., unsupervised and semi-supervised methods) as well as the extension to the multi-frame case, which is able to yield further accuracy improvements.Comment: To appear as a book chapter in Modelling Human Motion, N. Noceti, A. Sciutti and F. Rea, Eds., Springer, 202

Arthroscopic subscapularis bankart technique as a salvage procedure for failed anterior shoulder stabilization

BACKGROUND: Shoulder instability is a relatively common problem. Even with contemporary surgical techniques, instability can recur following both open and arthroscopic fixation. Surgical management of capsular insufficiency in anterior shoulder stabilization represents a significant challenge, particularly in young, active patients. There are a limited number of surgical treatment options. The Laterjet technique can present with a number of intraoperative challenges and postoperative complication.; DESCRIPTION OF TECHNIQUE: We report an arthroscopic subscapularis tenodesis technique as a salvage procedure for challenging glenohumeral instability cases. Sutures are passed through the subscapularis tendon and capsule before they are tied as one in the subdeltoid psace. The rotator interval is closed with superior and medial advancement of anterior and inferior tissue. This technical note carefully describes this procedure with useful technical tips, illustrations, and diagrams.; PATIENTS AND METHODS: Two clinical cases are described involving patients with recurrent instability following failed surgery who were successfully managed with this procedure.; RESULTS: Both cases described resulted in improved shoulder stability, range of motion, and function following management with this surgical technique. This arthroscopic subscapularis tenodesis procedure is proposed as a useful alternative repair technique for cases of recurrent instability after failed surgery with isolated capsular insufficiency.; CONCLUSION: It is believed that this arthroscopic subscapularis tenodesis technique can potentially provide similar outcomes to open bone block stabilization procedures, while reducing the risks associated with those procedures